In its first 100 days, the Trump administration’s “America First” rhetoric and actions have led to an increased focus on national security and a retreat from international institutions. In particular, these early days have been marked by disengagement from or attacks on international human rights systems that play a key role in the protection of women’s rights. For all their shortcomings—including their own historic gender biases—international human rights norms and institutions provide an advocacy space for groups whose dignity, worth, agency, or security have been systematically undermined by state policy and practice. This has been especially true for the rights of women. We have observed retreats from human rights at home, from human rights in foreign policy, and from the spaces and practices designed to uphold women’s rights globally. Here, we highlight some of the human rights effects of the fledgling administration’s actions—and inactions.